Overview
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This free course, Intracellular transport, explains the function of the cytoskeleton and its role in controlling transport of vesicles between different subcellular compartments.
Syllabus
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- Introduction
- Learning outcomes
- 1 The cytoskeleton
- 1 The cytoskeleton
- 1.1 Microtubules and microfilaments
- 1.2 Polymerisation and depolymerisation of actin
- 1.3 Polymerisation and depolymerisation of tubulin
- 1.4 Specialised intermediate filaments
- 1.5 Summary
- 2 Cellular compartments and traffic
- 2 Cellular compartments and traffic
- 2.1 Introduction
- 2.2 Traffic in the endoplasmic reticulum and the Golgi network
- 2.3 Sorting for the basolateral and apical zones of the plasma membrane
- 2.4 Exocytosis and the secretory pathways
- 2.5 The endocytic pathways and lysosomes
- 2.6 Transcytosis
- 2.7 Summary
- 3 Trafficking vesicles
- 3 Trafficking vesicles
- 3.1 Introduction
- 3.2 Formation of clathrin and COP-coated vesicles
- 3.3 Fusion of vesicles with the target membrane
- 3.4 The function of Rab proteins in directing traffic
- 3.5 Cycling and re-use of membranes and traffic proteins
- 3.6 Membrane fusion mediated by viral proteins
- 3.7 Summary
- 4 Signals for compartmentalisation
- 4 Signals for compartmentalisation
- 4.1 Introduction
- 4.2 Peptide signal sequences
- 4.3 Glycosylation sequences and protein glycosylation
- 4.4 Lipidation
- 4.5 Summary
- 5 The cytoskeleton and motor proteins
- 5 The cytoskeleton and motor proteins
- 5.1 The role of the cytoskeleton in intracellular transport
- 5.2 Motor proteins
- 5.3 Summary
- 6 Endocytic pathways
- 6 Endocytic pathways
- 6.1 Introduction
- 6.2 Endocytosis
- 6.3 Uncoupling and receptor recycling
- 6.4 Phagocytosis
- 6.5 Lysosomes
- 6.6 Special endosomal compartments
- 6.7 Summary
- 7 Exocytosis
- 7 Exocytosis
- 7.1 Introduction
- 7.2 Triggering systems
- 7.3 Regulation of secretion
- 7.4 Summary
- Conclusion
- References
- Acknowledgements
