Introduction to Tissue Engineering

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Free Online Course: Introduction to Tissue Engineering provided by Coursera is a comprehensive online course, which lasts for 2-5 hours a week. The course is taught in English and is free of charge. Upon completion of the course, you can receive an e-certificate from Coursera. Introduction to Tissue Engineering is taught by Dr. Yaakov Nahmias.

Overview
  • Tissue Engineering is a rapidly expanding field of applied biology and biomedical engineering that aims to create artificial organs for transplantation, basic research, or drug development. A fascinating aspect of the field is the fundamental need to integrate knowledge of organic chemistry, cell biology, genetics, mechanics and transport processes to create functional organs. The process uncovers the fascinating complexity of living tissues, and the joy of creation.  

    This course will review basic cell culture techniques, structure function relationships, cellular communication, natural and artificial biomaterials, and the basic equations governing cell survival and tissue organization. 

Syllabus
  • Week One: Introduction. definitions, basic principles, structure-function relationships

    Week Two: Biomaterials. metals, ceramics, polymers (synthetic and natural). Biodegradable materials, ative matrix

    Week Three: Tissue culture basics: primary cells vs. cell lines, sterile techniques, plastics, enzymes, eactors and cryopreservation

    Week Four: Oxygen transport. diffusion, Michalies-Menten kinetics, oxygen uptake rates, limits of diffusion

    Week Five: Principals of self assembly. cell migration, 3D organization and angiogenesis

    Week Six: Skin tissue engineering. introduction, scar vs. regeneration, split skin graft, apligraf

    Week Seven: Cardiovascula issue engineering. introduction, blood vessels structure, vascular grafts

    Week Eight: Liver tissue engineering. bioartificial liver (BAL) assist device, shear forces , oxyge ansport, plasma effects  

    Week Nine: Liver tissue engineering. self-assembled organoids, decelluarized whole livers

    Week Ten: Stem cells. basic principles, embryonic stem cells, induced pluripotent stem cells