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- Understand how to handle laboratory mice responsibly according to federal law by completing Institutional Animal Care and Use Committee (IACUC) training.
- Understand how research on animals must be scientifically justified, humane and ethical, and provide new knowledge.
- Collect behavioral data from mouse videos from compulsive-like, non-compulsive-like, and randomly bred mouse strains; a mouse model of obsessive-compulsive disorder (OCD).
- Obtain competency in using behavioral tests to measure compulsions in laboratory mice.
- Establish a foundation in using behavioral tests in laboratory mice to be able to confidently learn how to use new tests.
- Develop an ability to analyze behavioral data.
- Develop an ability to interpret and discuss results in the context of human psychiatric disorders and the mouse model of OCD.
- Obtain a competency in describing key characteristics of OCD in humans and compulsions in animal models.
- Develop a capability to formulate original research hypotheses.
- Obtain a competency in describing and discussing how basic research contributes to the animal model of OCD and how it may have the potential to contribute to improving the human condition.
- Learners who join this course should be free of objections to using mice in research.
Overview
Syllabus
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Module 1: Introduction, Animal Care and Training
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Module 2: Ethics of Animal Research
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Module 3: OCD in humans and compulsive like behavior in mice (nesting)
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Module 4: Compulsive-like behavior: Data collection and analysis of marble burying behavior
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Module 5: Interpretation of results
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